BiologicalActivity
PotentATMkinaseinhibitor(IC50=6.3nM).Exhibitslittletonononspecifictargeteffectsagainstapanelof229proteinkinases;displayssimilartargetselectivitytoKU55933(Cat.No.3544).Inhibitsmigrationandinvasionofhumangliomacellsinvitro.
LicensingInformation
SoldwiththepermissionofAstraZeneca.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofKU60019isreviewedonthechemicalprobeswebsite.
CompoundLibraries
KU60019isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 547.67 |
| Formula | C30H33N3O5S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 925701-46-8 |
| PubChemID | 15953870 |
| InChIKey | SCELLOWTHJGVIC-BGYRXZFFSA-N |
| Smiles | O=C(CN4C[C@H](C)O[C@H](C)C4)NC(C=C3)=CC2=C3SC1=C(C5=CC(C=C(N6CCOCC6)O5)=O)C=CC=C1C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.77 | 100 | |
| ethanol | 54.77 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight547.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.83mL | 9.13mL | 18.26mL |
| 5mM | 0.37mL | 1.83mL | 3.65mL |
| 10mM | 0.18mL | 0.91mL | 1.83mL |
| 50mM | 0.04mL | 0.18mL | 0.37mL |
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ProductDatasheets
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