Biological Activity
Selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.
Technical Data
| M. Wt | 545.52 |
| Formula | C22H22FN3O3.C4H6O6 |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 83846-83-7 |
| PubChem ID | 135348 |
| InChI Key | KMTLTEVOQLMYRS-UHFFFAOYSA-N |
| Smiles | OC(C(O)C(O)=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=O)NC3=CC=CC=C3C2=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.55 | 100 | |
| water | 5.45 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 545.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.83 mL | 9.17 mL | 18.33 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.67 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.83 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Leyson et al (1981) Receptor binding profile of R41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 28 1015 PMID: 6261070
Razzaque et al (1995) Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein. Eur.J.Pharmacol. 283 199 PMID: 7498311
Van Nueten et al (1981) Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors. J.Pharmacol.Exp.Ther. 218 217 PMID: 6113280
Zgombick et al (1995) Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes. Eur.J.Pharmacol. 291 9 PMID: 8549648
Keywords: Ketanserin tartrate, supplier, Selective, 5-HT2A, antagonist, 5-HT1D, Serotonin, Receptors, R41468, R, 41, 468, 5-HT2A, Receptors, 5-HT2A, Receptors, Tocris Bioscience
