Tocris/Ki 20227/4481/10/10毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Ki 20227/4481/10/10毫克

Tocris/Ki 20227/4481/10/10毫克

商品编号： 4481/10

品牌： Tocris Bioscience

市场价： ¥5100.00

美元价： 3060.00

产地：美国(厂家直采)

公司：

产品分类：激酶

公司分类： kinase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:c-Fmsinhibitor;suppressesosteolysisandosteoclastaccumulation

ChemicalName:N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofc-Fmstyrosinekinase(M-CSFR,CSF1R)(IC₅₀valuesare2,12,217and451nMforc-Fms,VEGFR-2,PDGFRβandc-Kitrespectively).DoesnotinhibitFlt3,EGFRorc-Src.Suppressesosteoclastdifferentiationandosteolysisinaratbonemetastasismodel.

CompoundLibraries

Ki20227isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	480.54
Formula	C₂₄H₂₄N₄O₅S
Storage	Storeat+4°C
Purity	≥97%(HPLC)
CASNumber	623142-96-1
PubChemID	9869779
InChIKey	SHPFDGWALWEPGS-UHFFFAOYSA-N
Smiles	O=C(NC(C)C3=NC=CS3)NC(C(OC)=C2)=CC=C2OC1=C4C(C=C(OC)C(OC)=C4)=NC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	48.05	100
	ethanol	4.81	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight480.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.08mL	10.4mL	20.81mL
5mM	0.42mL	2.08mL	4.16mL
10mM	0.21mL	1.04mL	2.08mL
50mM	0.04mL	0.21mL	0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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