Biological Activity
kisspeptin receptor (KISS1, GPR54) antagonist; kisspeptin-10 (Cat. No. 2570) analog. Inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH).
Licensing Information
Sold under license
Technical Data
| M. Wt | 1295.42 |
| Formula | C63H78N18O13 |
| Sequence |
Ac-ANWNGFGWRF-NH2 (Modifications: Ala-1 = D-Ala & N-terminal Ac, Trp-8 = D-Trp, Phe-10 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 1145998-81-7 |
| PubChem ID | 90488890 |
| InChI Key | IUPKBWSKNCAQJQ-JYYYXURSSA-N |
| Smiles | C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1295.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.77 mL | 3.86 mL | 7.72 mL |
| 5 mM | 0.15 mL | 0.77 mL | 1.54 mL |
| 10 mM | 0.08 mL | 0.39 mL | 0.77 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. 29 3920 PMID: 19321788
Keywords: Kisspeptin 234, supplier, KISS1, GPR54, antagonists, kisspeptin10, kisspeptin_10, analogs, analogues, Kisspeptin234, Kisspeptin, Receptor, Kisspeptin, Receptor, Tocris Bioscience
