Biological Activity
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.
Technical Data
| M. Wt | 449.79 |
| Formula | C15H11ClF3N5O4S |
| Storage | Store at +4°C |
| CAS Number | 436133-68-5 |
| PubChem ID | 3827663 |
| InChI Key | KSJVAYBCXSURMQ-UHFFFAOYSA-N |
| Smiles | CC1=C(Cl)C=C(NC(NNC2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2[N+]([O-])=O)=S)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 4.5 | 10mM with gentle warming | |
| water | 2.25 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 449.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.12 mL | 22.23 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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References
References are publications that support the products' biological activity.
Shima et al (2013) In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 110 8182 PMID: 23630290
Keywords: Kobe 0065, supplier, Kobe0065, H-ras-GTP, cRaf, interaction, inhibitors, inhibits, orally, active, Raf, Kinase, G, Proteins, (Small), GTPase, Raf, Kinase, Tocris Bioscience
