Biological Activity
Sodium salt of kynurenic acid (Cat. No. 0223), a broad spectrum EAA antagonist.
Technical Data
| M. Wt | 211.15 |
| Formula | C10H6NNaO3 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 2439-02-3 |
| PubChem ID | 52974250 |
| InChI Key | RCAZGXKUQDXSSK-UHFFFAOYSA-M |
| Smiles | [Na+].OC1=CC(=NC2=CC=CC=C12)C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.56 | 50 | |
| water | 21.11 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 211.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.74 mL | 23.68 mL | 47.36 mL |
| 5 mM | 0.95 mL | 4.74 mL | 9.47 mL |
| 10 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.95 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Perkins and Stone (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 247 184 PMID: 6215086
Pittaluga et al (1997) The 'kynurenate test', a biochemical assay for putative cognition enhancers. J.Pharmacol.Exp.Ther. 283 82 PMID: 9336311
Wang et al (2006) Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J.Biol.Chem. 281 22021 PMID: 16754668
Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Progr.Neurobiol. 30 333 PMID:
Keywords: Kynurenic acid sodium salt, supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, Ionotropic, Glutamate, GPR35, Non-selective, Ionotropic, Glutamate, Tocris Bioscience
