Biological Activity
Potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively).
Technical Data
| M. Wt | 539.71 |
| Formula | C33H41N5O2 |
| Storage | Store at +4°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 208706-12-1 |
| PubChem ID | 9915239 |
| InChI Key | DAMXHAMKVXERLM-FVBCXUTKSA-N |
| Smiles | NC[C@H]1CCC[C@@H](CNC([C@H](NC(N4CCC5(C(C=CC=C6)=C6C=C5)CC4)=O)CC2=CNC3=C2C=CC=C3)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.99 | 50 | |
| ethanol | 53.97 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 539.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.85 mL | 9.26 mL | 18.53 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.85 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Yang et al (1998) Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J.Med.Chem. 41 2175 PMID: 9632348
Keywords: (1R,1S,3R/1R,1R,3'S)-L-054,264, supplier, Potent, selective, sst2, agonists, sst, Receptors, Somatostatin, (1R,1S,3R/1R,1R,3S)-L-054,264, L054264, Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience
