Biological Activity
Potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.
Compound Libraries
L-165,041 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 402.44 |
| Formula | C22H26O7 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 79558-09-1 |
| PubChem ID | 4364841 |
| InChI Key | YBEZORYMVISYOA-UHFFFAOYSA-N |
| Smiles | CCCC1=C(O)C(CC=O)=CC=C1OCCCOC1=CC=C(OCC(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 40.24 | 100 | |
| DMSO | 40.24 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 402.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.42 mL | 24.85 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.97 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Berger et al (1999) Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects. J.Biol.Chem. 274 6718 PMID: 10037770
Iwashita et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo. J.Pharmacol.Exp.Ther. 320 1087 PMID: 17167170
Leibowitz et al (2000) Activation of PPARδ alters lipid metabolism in db/db mice. FEBS Lett. 473 333 PMID: 10818235
Keywords: L-165,041, supplier, Potent, PPARδ, PPARdelta, agonists, Peroxisome, Proliferator-Activating, Receptors, agonist, L165041, PPARdelta, Receptors, PPARdelta, Receptors, Tocris Bioscience
