Biological Activity
Activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
Technical Data
| M. Wt | 397.44 |
| Formula | C25H20FN3O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 103342-82-1 |
| PubChem ID | 656755 |
| InChI Key | CGBANSGENFERAT-JOCHJYFZSA-N |
| Smiles | CN(C1=CC=CC=C1C(C5=CC=CC=C5F)=N[C@@H]2CC3=CNC4=C3C=CC=C4)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.74 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 397.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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References
References are publications that support the products' biological activity.
Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941 PMID: 14576198
Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443 PMID: 16945016
Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220 PMID:
Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377 PMID: 22251082
Keywords: L-364,373, supplier, KCNQ1, KVLQT1, kv7.1, channel, activators, activates, IKs, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, L364373, R-L3, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience
