BiologicalActivity
Potent,selectiveinverseagonistforthebenzodiazepinesiteofGABAAreceptorscontainingtheα5subunit(Ki=0.45nM).Displays50-100-foldselectivityoverGABAAreceptorscontainingα1,α2,α3orα6subunitsincombinationwithβ3andγ2.EnhancesLTPin amousehippocampalslicemodelandincreasesspatiallearning,withoutdisplayingproconvulsantactivity.
CompoundLibraries
L-655,708isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 341.37 |
| Formula | C18H19N3O4 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 130477-52-0 |
| PubChemID | 5311203 |
| InChIKey | YKYOQIXTECBVBB-AWEZNQCLSA-N |
| Smiles | O=C(N3[C@]([H])2CCC3)C4=C(C=CC(OC)=C4)N1C2=C(C(OCC)=O)N=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.53 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight341.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.93mL | 14.65mL | 29.29mL |
| 5mM | 0.59mL | 2.93mL | 5.86mL |
| 10mM | 0.29mL | 1.46mL | 2.93mL |
| 50mM | 0.06mL | 0.29mL | 0.59mL |
MolarityCalculator
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ProductDatasheets
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