Tocris/L-670,596/1949/10/10 mg-免疫在线蚂蚁淘旗下平台

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Tocris/L-670,596/1949/10/10 mg

商品编号： 1949/10

品牌： Tocris Bioscience

市场价： ¥3780.00

美元价： 2268.00

产地：美国(厂家直采)

公司：

产品分类：受体

公司分类： Receptors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description: Potent, selective thromboxane A₂/prostaglandin endoperoxide antagonist

Chemical Name: (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective thromboxane A₂/prostaglandin endoperoxide receptor antagonist (IC₅₀ = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA₂ = 9.0) and human platelet aggregation in vitro (IC₅₀ = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo.

Technical Data

M. Wt	433.47
Formula	C₂₂H₂₁F₂NO₄S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	121083-05-4
PubChem ID	129360
InChI Key	GMJWAIMJHBTYPD-UHFFFAOYSA-N
Smiles	CS(=O)(=O)C1=CC=C(CN2C3=C(CCCC3CC(O)=O)C3=CC(F)=CC(F)=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH	43.35	100

Preparing Stock Solutions

The following data is based on the product molecular weight 433.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.53 mL	23.07 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ford-Hutchinson et al (1989) The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can.J.Physiol.Pharmacol. 67 989 PMID: 2598135

Girard et al (1989) Tetrahydrocarbazol-1-acetic acids: new class of thromboxane receptor antagonists. Prog.Clin.Biol.Res. 301 585 PMID: 2529558

Beauchamp et al (2001) Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy. J.Appl.Physiol. 90 2279 PMID: 11356793

Keywords: L-670,596, supplier, Potent, selective, thromboxane, A2, endoperoxide, antagonists, TP, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L670596, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience

品牌介绍

Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。 Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。 Tocris Bioscience的主要产品包括： Small Molecules Peptides Aptamers Controlled Substances Compound Libraries DREADD Ligands Fluorescent Imaging Ligand Sets Optopharmacology Reagents Toxins 按照研究领域细分： Cancer Cardiovascular System Endocrinology Immunology Neuroscience Pain & Inflammation Respiratory System

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