Biological Activity
An antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant.
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Technical Data
| M. Wt | 263.68 |
| Formula | C13H10ClNO3 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 151057-13-5 |
| PubChem ID | 54687453 |
| InChI Key | MXEFWCFPCLDOOG-UHFFFAOYSA-N |
| Smiles | OC1=C(C(=O)C2CC2)C(=O)NC2=C1C=CC(Cl)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 50 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 263.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.79 mL | 18.96 mL | 37.92 mL |
| 5 mM | 0.76 mL | 3.79 mL | 7.58 mL |
| 10 mM | 0.38 mL | 1.9 mL | 3.79 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Rowley et al (1993) 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex. J.Med.Chem. 36 3386 PMID: 8230129
Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149 PMID: 10740291
Keywords: L-701,252, supplier, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, anticonvulsant, L701252, merck, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
