Biological Activity
An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Compound Libraries
L-701,324 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 363.8 |
| Formula | C21H14ClNO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 142326-59-8 |
| PubChem ID | 54682505 |
| InChI Key | FLVRDMUHUXVRET-UHFFFAOYSA-N |
| Smiles | OC1=C(C(=O)NC2=CC(Cl)=CC=C12)C1=CC=CC(OC2=CC=CC=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 363.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.74 mL | 27.49 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.75 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bristow et al (1996) The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324 in rodents. J.Pharmacol.Exp.Ther. 277 578 PMID: 8627534
Bristow et al (1996) Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex. J.Pharmacol.Exp.Ther. 279 492 PMID: 8930150
Kulagowski et al (1994) 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 37 1402 PMID: 8182696
Obrenovitch and Zilkha (1996) Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-methyl-D-aspartate receptor complex. Br.J.Pharmacol. 117 931 PMID: 8851513
Keywords: L-701,324, supplier, NMDA, antagonist, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, L701324, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
