Biological Activity
5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).
Licensing Information
Sold with the permission of Merck, Sharpe and Dohme Ltd.
Technical Data
| M. Wt | 454.54 |
| Formula | C16H24N4O2S.C4H6O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 144776-01-2 |
| PubChem ID | 90488774 |
| InChI Key | WLXRLNXDMGIORD-UHFFFAOYSA-N |
| Smiles | O=S1(N(CCN1C)CC2=CC=C(NC=C3CCN(C)C)C3=C2)=O.O=C(CCC(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.45 | 100 | |
| water | 22.73 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 454.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.2 mL | 11 mL | 22 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.2 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Castro et al (1994) Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor. J.Med.Chem. 37 3023 PMID: 7932524
Keywords: L-703,664 succinate, supplier, Selective, 5-HT1D, receptor, agonists, Serotonin, Receptors, L703664, 5-HT1D, Receptors, 5-HT1D, Receptors, Tocris Bioscience
