Biological Activity
Increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.
Technical Data
| M. Wt | 293.39 |
| Formula | C17H15N3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 894002-50-7 |
| PubChem ID | 7207425 |
| InChI Key | DUUQLWDHNYFUPP-UHFFFAOYSA-N |
| Smiles | CC1=CC=CC=C1CSC(N=N3)=CC=C3C2=NC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.34 | 100 | |
| ethanol | 5.87 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 293.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.41 mL | 17.04 mL | 34.08 mL |
| 5 mM | 0.68 mL | 3.41 mL | 6.82 mL |
| 10 mM | 0.34 mL | 1.7 mL | 3.41 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lin et al (2012) Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 4 1689 PMID: 22924507
Xing et al (2011) Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg.Med.Chem.Lett. 21 5774 PMID: 21875806
Lin et al (2013) : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression . Society for Neuroscience (Abstract) 99 PMID:
Takahashi et al (2013) A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer’s-like pathologies and memory deficits in APPSw/Ind mice. Society for Neuroscience (Abstract) 103 PMID:
Keywords: LDN 212320, supplier, LDN212320, glutamate, transporters, EAAT2, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitters, Alzheimer's, disease, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience
