BiologicalActivity
Selectivehistonedeacetylase(HDAC)4andHDAC5inhibitor(IC50valuesare4.22,11.9,55.7,320,852,881,and1278nMforHDAC5,4,6,1,11,2,and8,respectively).DemonstratesactivityagainstchemoresistantcancercelllinesinanMTTassayforcytotoxicityusinghumanovariancancercelllinesA2780andcisplatinresistantA2780CisR(IC50=0.49and0.32μMrespectively).
CompoundLibraries
LMK235isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 294.35 |
| Formula | C15H22N2O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1418033-25-6 |
| PubChemID | 71520717 |
| InChIKey | VRYZCEONIWEUAV-UHFFFAOYSA-N |
| Smiles | CC1=CC(C(NOCCCCCC(NO)=O)=O)=CC(C)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.43 | 100 | |
| ethanol | 29.43 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight294.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.4mL | 16.99mL | 33.97mL |
| 5mM | 0.68mL | 3.4mL | 6.79mL |
| 10mM | 0.34mL | 1.7mL | 3.4mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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ProductDatasheets
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