Biological Activity
5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.22, 7.3, 52.7 and 326 nM respectively). Induces relaxation of substance P-induced contractions in guinea pig ileum (EC50 = 1.77 μM).
Licensing Information
Sold under license from the University of Bari
Technical Data
| M. Wt | 518.13 |
| Formula | C32H39N3O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1185136-22-4 |
| PubChem ID | 56972187 |
| InChI Key | XNDUOTNYUWDFKR-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCN3CCN(C4=C(C5=CC=CC=C5)C=CC=C4)CC3)NC2CCCC1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.86 | 75 | |
| ethanol | 38.86 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 518.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.93 mL | 9.65 mL | 19.3 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.93 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Leopoldo et al (2007) Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J.Med.Chem. 50 4214 PMID: 17649988
Keywords: LP 12 hydrochloride, supplier, 5-HT7, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, LP12, hydrochloride, 5-HT7, Receptors, 5-HT7, Receptors, Tocris Bioscience
