Biological Activity
Ligand of the 5-HT7 receptor (Ki = 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1 and 5-HT1A receptors (Ki values are 156 and 476 nM respectively).
Licensing Information
Sold under license from the University of Bari
Technical Data
| M. Wt | 304.81 |
| Formula | C17H20N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1386928-34-2 |
| PubChem ID | 22001617 |
| InChI Key | KXZUJPBDJNUNCN-UHFFFAOYSA-N |
| Smiles | COC(C=C3)=CC=C3C1=CC=CC=C1N2CCNCC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.48 | 100 | |
| water | 15.24 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 304.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.28 mL | 16.4 mL | 32.81 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.56 mL |
| 10 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lacivita et al (2012) Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. J.Med.Chem. 55 6375 PMID: 22738316
Keywords: LP 20 hydrochloride, supplier, LP20, 5-HT7, ligands, selective, serotonergics, 5-HT7, Receptors, 5-HT7, Receptors, Tocris Bioscience
