BiologicalActivity
Potentandselectiveinhibitorofleucine-richrepeatkinase2(LRRK2).InhibitsbothG2019Smutantandwild-typeLRRK2kinaseactivity(IC50valuesare6and13nMrespectively).Causesdephosphorylation,ubiquitinationanddegradationofLRRK2.
LicensingInformation
SoldunderlicensefromtheDana-FarberCancerInstitute.
CompoundLibraries
LRRK2-IN-1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 570.09 |
| Formula | C31H38N8O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1234480-84-2 |
| PubChemID | 46843906 |
| InChIKey | IWMCPJZTADUIFX-UHFFFAOYSA-N |
| Smiles | O=C2C3=C(C=CC=C3)N(C)C1=NC(NC4=C(OC)C=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4)=NC=C1N2C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.01 | 100 | |
| ethanol | 57.01 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight570.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.75mL | 8.77mL | 17.54mL |
| 5mM | 0.35mL | 1.75mL | 3.51mL |
| 10mM | 0.18mL | 0.88mL | 1.75mL |
| 50mM | 0.04mL | 0.18mL | 0.35mL |
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