Biological Activity
Potent DNA-PK inhibitor (IC50 = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro.
Technical Data
| M. Wt | 414.48 |
| Formula | C24H18N2O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1879887-96-3 |
| PubChem ID | 122705987 |
| InChI Key | SMMSWOMXOZLOPI-UHFFFAOYSA-N |
| Smiles | O=C1C2=C(C(C3=CC=CC4=C3SC5=C4C=CC=C5)=CC=C2)OC(N6CCOCC6)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.72 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 414.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.06 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Morrison et al (2016) Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 110 326 PMID: 26854431
Keywords: LTURM 34, supplier, LTURM34, potent, DNA-PK, inhibitors, inhibits, DAN-dependent, protein, kinases, DNA-dependent, Protein, Kinase, DNA-dependent, Protein, Kinase, Tocris Bioscience
