Biological Activity
Allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.
Technical Data
| M. Wt | 318.39 |
| Formula | C15H11FN2OS2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 913186-74-0 |
| PubChem ID | 11964458 |
| InChI Key | PEAMDZVDNYENPN-UHFFFAOYSA-N |
| Smiles | O=C(C3=CSC=C3)C1=C(C)N=C(NC2=CC=C(F)C=C2)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.84 | 100 | |
| ethanol | 3.18 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 318.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.41 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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References
References are publications that support the products' biological activity.
Broad et al (2006) Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J.Pharmacol.Exp.Ther. 318 1108 PMID: 16738207
Young et al (2008) Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci. 105 14686 PMID:
Keywords: LY 2087101, supplier, allosteric, potentiators, modulators, nicotinic, acetylcholine, receptors, nAChRs, alpha7, α7, a7, LY2087101, Nicotinic, (a7), Receptors, Nicotinic, (a4b2), Receptors, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, (a7), Receptors, Tocris Bioscience
