Biological Activity
Competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.
Licensing Information
Sold with the permission of Eli Lilly and Company
Technical Data
| M. Wt | 211.22 |
| Formula | C8H13N5O2 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 125546-04-5 |
| PubChem ID | 90479799 |
| InChI Key | RTVQJOXSBRCZBN-JUKSSJACSA-N |
| Smiles | O=[C@@]([C@@H]1C[C@H](CC2=NN=NN2)CCN1)O.O=C([C@H]3C[C@@H](CC4=NN=NN4)CCN3)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.12 | 100 | |
| water | 21.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 211.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.73 mL | 23.67 mL | 47.34 mL |
| 5 mM | 0.95 mL | 4.73 mL | 9.47 mL |
| 10 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.95 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Schoepp et al (1990) Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action. J.Pharmacol.Exp.Ther. 255 1301 PMID: 2148188
Madden et al (1992) Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. J.Neurosurg. 76 106 PMID: 1727148
Madden et al (1993) Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate antagonists in rabbits. Stroke 24 1068 PMID: 8322381
Keywords: LY 233053, supplier, Competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, LY233053, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
