Biological Activity
Selective 5-HT2B receptor antagonist (pKi = 9.3). More than 100-fold selective over 5-HT2A and 5-HT2C. Attenuates amphetamine-induced locomotion in the rat.
Compound Libraries
LY 266097 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 407.33 |
| Formula | C21H23ClN2O2.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 172895-39-5 |
| PubChem ID | 9953184 |
| InChI Key | KPXKZZURYAXZQE-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4Cl)C2=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.73 | 100 | |
| ethanol | 40.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 407.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.28 mL | 24.55 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Audia et al (1996) Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5-HT2B) contractile receptor in the rat stomach fundus. J.Med.Chem. 39 2773 PMID: 8709108
Auclair et al (2010) The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity. J.Neurochem. 114 1323 PMID: 20534001
Keywords: LY 266097 hydrochloride, supplier, LY266097, HCl, 5HT2B, 5ht-2b, receptor, antagonists, 5-ht2b, antagonist, serotonin, serotonergic, 2B, receptors, 5-HT2B, Receptors, 5-HT2B, Receptors, Tocris Bioscience
