BiologicalActivity
NegativecontrolcompoundwithrespecttoLY294002(Cat.No.1130)PI3-kinaseinhibitoryactivity.Blocksvoltage-gatedpotassium(Kv)channels(IC50=64.6μM)andinhibitsIL-1β-stimulatedNF-κBactivation,attenuatingMCP-1expression.Antiproliferative.AlsoinhibitstheBETbromodomainproteinsBRD2,BRD3andBRD4.
CompoundLibraries
LY303511isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 306.36 |
| Formula | C19H18N2O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 154447-38-8 |
| PubChemID | 3971 |
| InChIKey | NGAGMBNBKCDCDJ-UHFFFAOYSA-N |
| Smiles | O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCNCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 30.64 | 100 | |
| DMSO | 30.64 | 100 | |
| ethanol | 30.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight306.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.26mL | 16.32mL | 32.64mL |
| 5mM | 0.65mL | 3.26mL | 6.53mL |
| 10mM | 0.33mL | 1.63mL | 3.26mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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