Biological Activity
5-HT1D-preferring receptor antagonist (EC50 = 31 nM). Displays no activity on 5-HT transport.
Licensing Information
Sold under license from Eli Lilly and company
Technical Data
| M. Wt | 430.94 |
| Formula | C24H27FN2O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 192927-92-7 |
| PubChem ID | 11957576 |
| InChI Key | BOCLFQZPFYNVFD-UHFFFAOYSA-N |
| Smiles | CC(C1=CC=CC=C1N2CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)(C)C2=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.09 | 100 | |
| ethanol | 10.77 | 25 | |
| water | 4.31 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 430.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.6 mL | 23.21 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Pullar et al (2004) The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur.J.Pharmacol. 493 85 PMID: 15189767
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