Biological Activity
Selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects.
Licensing Information
Sold under license from Eli Lilly and company
Technical Data
| M. Wt | 387.88 |
| Formula | C21H22FN3O.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 199673-74-0 |
| PubChem ID | 19710026 |
| InChI Key | DGPDGAPZTPSHBL-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(F)C=C4)NC1=CC=C(NC=C2C3CCN(C)CC3)C2=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.7 | 25mM with gentle warming | |
| water | 9.7 | 25mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 387.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.58 mL | 12.89 mL | 25.78 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.16 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.58 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Dupuis et al (1998) G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines. Br.J.Pharmacol. 124 283 PMID: 9641544
Shepheard et al (1999) Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370. Cephalalgia 19 851 PMID: 10668103
Wainscott et al (2005) [H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn-Schmied.Arch.Pharmacol. 371 169 PMID:
Keywords: LY 334370 hydrochloride, supplier, Selective, 5-HT1F, agonists, Serotonin, Receptors, LY334370, hydrochloride, 5-HT1F, Receptors, 5-HT1F, Receptors, Tocris Bioscience
