Biological Activity
Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 (Cat. No. 1209).
Technical Data
| M. Wt | 397.33 |
| Formula | C20H17NNa2O5 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| PubChem ID | 90488907 |
| InChI Key | UYFREPWOVKMBOV-AUZVYACCSA-L |
| Smiles | [Na+].[Na+].[H][C@@]1(C[C@@H]1C([O-])=O)[C@@](N)(CC1C2=CC=CC=C2OC2=C1C=CC=C2)C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 39.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 397.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.17 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fitzjohn et al (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology 37 1445 PMID: 9886667
Ornstein et al (1998) 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav J.Med.Chem. 41 358 PMID: 9464367
Johnson et al (1999) [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 38 1519 PMID: 10530814
Keywords: LY 341495 disodium salt, supplier, LY341495, disodium, salt, group, II, mglu, metabotropic, glutamate, receptors, antagonists, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience
