BiologicalActivity
SelectiveinhibitorofTGF-βtype-Ireceptor(TGF-βRI,TGFR-I,TβR-I,ALK-5)(IC50valuesare59,400and1400nMforTGR-βRI,TGF-βRIIandMLK-7Krespectively).InhibitsTGF-β-dependentluciferaseproductioninminklungcells(p3TPlux)andgrowthinmousefibroblasts(NIH3T3)(IC50valuesare47and89nMrespectively).SuppressesinvasionofMDA-MB-231breastcancercellsinamatrigelinvasionassay.
CompoundLibraries
LY364947isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 272.31 |
| Formula | C17H12N4 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 396129-53-6 |
| PubChemID | 447966 |
| InChIKey | IBCXZJCWDGCXQT-UHFFFAOYSA-N |
| Smiles | N1C=C(C(=N1)C1=CC=CC=N1)C1=CC=NC2=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.23 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight272.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.67mL | 18.36mL | 36.72mL |
| 5mM | 0.73mL | 3.67mL | 7.34mL |
| 10mM | 0.37mL | 1.84mL | 3.67mL |
| 50mM | 0.07mL | 0.37mL | 0.73mL |
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ProductDatasheets
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