BiologicalActivity
Photoswitchableepithelialsodiumchannel(ENaC)blocker(IC50valuesare90and390nMforαβγandδβγENaCs,respectively,inthetransconformation).Switchesconformationfromcistotransat500nmandtranstocisat400nm.BlocksENaCswithgreaterefficacyinthecisconformation,incomparisontothetransconformation,inXenopusoocytesandHEK293tcells.PartiallyblocksδβγENaCsinthetransconformationandexhibitsnearmaximalblockofδβγENaCsinthecisconformation.Amiloridederivative.
TechnicalData
| M.Wt | 482.75 |
| Formula | C18H16ClN9O.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 121513862 |
| InChIKey | JKZVQNCSFUAMFC-UHFFFAOYSA-N |
| Smiles | O=C(NC(NC2=CC=C(/N=N/C3=CC=CC=C3)C=C2)=N)C1=C(N)N=C(N)C(Cl)=N1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.27 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight482.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.07mL | 10.36mL | 20.71mL |
| 5mM | 0.41mL | 2.07mL | 4.14mL |
| 10mM | 0.21mL | 1.04mL | 2.07mL |
| 50mM | 0.04mL | 0.21mL | 0.41mL |
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