BiologicalActivity
HighlyselectivegroupIImGlureceptoragonist(EC50valuesare2.69and4.48nMforhmGlu2andhmGlu3respectively)thatdisplays>80-foldselectivityovergroupIandgroupIIIreceptors.ProvidesprotectionagainstNMDA-mediatedcelldeathinvitroandoffersalmostcompleteprotectionagainstCA1hippocampaldamagefollowingglobalischemiaingerbils.Orallyandsystemicallyactive.CagedLY379268isalsoavailable(Cat.No.3332).
LicensingInformation
SoldunderlicensefromEliLillyandCompany
TechnicalData
| M.Wt | 187.15 |
| Formula | C7H9NO5 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 191471-52-0 |
| PubChemID | 10197984 |
| InChIKey | YASVRZWVUGJELU-MDASVERJSA-N |
| Smiles | [H][C@]12[C@]([C@H]2[C@@](O)=O)([H])[C@](N)([C@](O)=O)CO1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 18.71 | 100 | |
| water | 3.74 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight187.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.34mL | 26.72mL | 53.43mL |
| 5mM | 1.07mL | 5.34mL | 10.69mL |
| 10mM | 0.53mL | 2.67mL | 5.34mL |
| 50mM | 0.11mL | 0.53mL | 1.07mL |
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ProductDatasheets
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