BiologicalActivity
SelectiveAMPAreceptorpositiveallostericmodulator(IC50valuesare0.15,0.21,1.66and5.65μMforGluA2i,GluA4i,GluA3iandGluA1irespectively).PotentiatesglutamateandAMPA-evokedcurrentsinprefrontalcortex(PFC)pyramidalneuronsinvitro.HasnoeffectonNMDA-orkainate-evokedcurrents;alsohasnoeffectonK+orNa+ionchannels.PotentiatesPFCglutamatergicsynaptictransmissioninvitroandinvivo.Inducesneuritegrowthincombinationwith(S)-AMPA(Cat.No.0254)inSH-SY5Yhumanneuroblastomacellsinvitro.AlsoreducesMPTP-inducedtoxicityinmice.Brainpenetrant.
CompoundLibraries
LY404187isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 342.46 |
| Formula | C19H22N2O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 211311-95-4 |
| PubChemID | 9928016 |
| InChIKey | HOQAVGZLYRYHSO-UHFFFAOYSA-N |
| Smiles | N#CC1=CC=C(C2=CC=C(C(C)CNS(C(C)C)(=O)=O)C=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.25 | 100 | |
| ethanol | 17.12 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight342.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.92mL | 14.6mL | 29.2mL |
| 5mM | 0.58mL | 2.92mL | 5.84mL |
| 10mM | 0.29mL | 1.46mL | 2.92mL |
| 50mM | 0.06mL | 0.29mL | 0.58mL |
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ProductDatasheets
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