Biological Activity
Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels. Water-soluble salt available (lamotrigine isethionate, Cat. No. 2289).
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data
| M. Wt | 256.09 |
| Formula | C9H7Cl2N5 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 84057-84-1 |
| PubChem ID | 3878 |
| InChI Key | PYZRQGJRPPTADH-UHFFFAOYSA-N |
| Smiles | NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.61 | 100 | |
| ethanol | 2.56 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 256.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.9 mL | 19.52 mL | 39.05 mL |
| 5 mM | 0.78 mL | 3.9 mL | 7.81 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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References
References are publications that support the products' biological activity.
Grunze et al (1998) Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 38 131 PMID: 9778600
Leach et al (1991) Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 S4 PMID: 1685439
Zheng et al (2010) The anticonvulsive drug lamotrigine blocks neuronal α4β2 nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 335 401 PMID: 20688974
Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMID: 9184596
Keywords: Lamotrigine, supplier, inhibitors, glutamate, release, Anticonvulsant, Blocks, Na+, K+, Ca2+, calcium, sodium, potassium, channels, inhibits, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Channel, modulators, VDAC, GlaxoSmithKline, GSK, Miscellaneous, Glutamate, Other, Channel, Modulators, Miscellaneous, Glutamate, Tocris Bioscience
