Biological Activity
Gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, LHRH) receptor agonist. Suppresses estradiol, LH and FSH serum levels and represses the growth of experimental rat endometriosis.
Technical Data
| M. Wt | 1209.41 |
| Formula | C59H84N16O12 |
| Sequence |
XHWSYLLRP (Modifications: X1 = Glp, Pro-9 = Pro-NHEt) |
| Storage | Desiccate at -20°C |
| CAS Number | 53714-56-0 |
| PubChem ID | 90488782 |
| InChI Key | GFIJNRVAKGFPGQ-UILVTTEASA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.50 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1209.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.83 mL | 4.13 mL | 8.27 mL |
| 5 mM | 0.17 mL | 0.83 mL | 1.65 mL |
| 10 mM | 0.08 mL | 0.41 mL | 0.83 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.17 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Okada et al (1988) One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats. J.Pharmacol.Exp.Ther. 244 744 PMID: 3126294
Uday et al (2007) LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice. Eur.J.Pharmacol. 563 155 PMID: 17368614
Salvador et al (2001) Effects of the luteinising hormone-releasing hormone (LH-RH) agonist leuprolide on adenylyl cyclase regulation through G-protein coupled receptors in rat ventral prostate. Eur.J.Pharmacol. 37 641 PMID:
Keywords: Leuprolide, supplier, GnRH, receptor, agonists, Receptors, Gonadotrophin-Releasing, Hormone, gonadotropin, chemotherapeutics, Leuoprorelin, Gonadotrophin-Releasing, Hormone, Receptors, Gonadotrophin-Releasing, Hormone, Receptors, Tocris Bioscience
