Biological Activity
Potent ERβ agonist isolated from licorice root (EC50 = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.
Technical Data
| M. Wt | 256.25 |
| Formula | C15H12O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 578-86-9 |
| PubChem ID | 114829 |
| InChI Key | FURUXTVZLHCCNA-AWEZNQCLSA-N |
| Smiles | OC(C=C3)=CC=[C@@]3[C@H](C2)OC1=CC(O)=CC=C1C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.52 | 100 | |
| ethanol | 26.52 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 256.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.9 mL | 19.51 mL | 39.02 mL |
| 5 mM | 0.78 mL | 3.9 mL | 7.8 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Yahara and Nishioka (1984) Flavonoid glucosides from licorice. Phytochemistry 23 2108 PMID:
Mersereau et al (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol.Cell.Endocrinol. 283 49 PMID: 18177995
Kim et al (2008) Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production. Br.J.Pharmacol. 154 165 PMID: 18332856
Keywords: Liquiritigenin, supplier, ERβ, ERb, ERbeta, selective, agonists, ERR, estrogen, receptors, anti-inflammatories, antiinflammatory, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience
