Biological Activity
Mood stabilizer; thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Effective in the treatment of bipolar disorder. Inhibits GSK-3 in vivo.
Technical Data
| M. Wt | 73.89 |
| Formula | Li2CO3 |
| Storage | Store at RT |
| CAS Number | 554-13-2 |
| PubChem ID | 11125 |
| InChI Key | XGZVUEUWXADBQD-UHFFFAOYSA-L |
| Smiles | [Li+].[Li+].[O-]C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.39 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 73.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 13.53 mL | 67.67 mL | 135.34 mL |
| 5 mM | 2.71 mL | 13.53 mL | 27.07 mL |
| 10 mM | 1.35 mL | 6.77 mL | 13.53 mL |
| 50 mM | 0.27 mL | 1.35 mL | 2.71 mL |
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References
References are publications that support the products' biological activity.
Lenox and Hahn (2000) Overview of the mechanism of action of lithium in the brain: fifty-year update. J.Clin.Psychiatry 61 5 PMID: 10826655
Gould et al (2004) In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 29 32 PMID: 12942141
Keywords: Lithium carbonate, supplier, Mood, stabilizers, sodium, potassium, Na+/K+, ATPase, pumps, bipolar, Na+/K+, ATPase, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, 3, Tocris Bioscience
