Biological Activity
Amphibian bombesin-like peptide. Stimulates smooth muscle contraction, gastrin release, gastric acid and pancreatic secretion, and suppresses food intake in vivo.
Technical Data
| M. Wt | 1085.25 |
| Formula | C51H68N14O11S |
| Sequence |
XQWAVGHFM (Modifications: X = Glp, Met-9 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 55749-97-8 |
| PubChem ID | 5486808 |
| InChI Key | OHCNRADJYUSTIV-FPNHNIPFSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 0.25% acetic acid |
Preparing Stock Solutions
The following data is based on the product molecular weight 1085.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.92 mL | 4.61 mL | 9.21 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 10 mM | 0.09 mL | 0.46 mL | 0.92 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Endean et al (1975) Parallel bioassay of bombesin and litorin, a bombesin-like peptide from the skin of Litoria aurea. Br.J.Pharmacol. 55 213 PMID: 1201379
Kulkosky and Gibbs (1982) Litorin suppresses food intake in rats. Life Sci. 31 685 PMID: 6290821
Lin et al (1995) Comparison of the peptide structural requirements for high affinity interaction with bombesin receptors. Eur.J.Pharmacol. 294 55 PMID: 8788416
Keywords: Litorin, supplier, Amphibian, bombesin-like, peptide, GRP-Preferring, Receptors, BB1-3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, Bombesin, Receptors, Bombesin, Receptors, Tocris Bioscience
