Biological Activity
High affinity, partial agonist with a Ki value of 4.4 nM in rat brain.
Technical Data
| M. Wt | 373.92 |
| Formula | C22H27NO2.HCl |
| Storage | Store at RT |
| CAS Number | 134-63-4 |
| PubChem ID | 11527152 |
| InChI Key | LPMXVESGRSUGHW-VGFRVVOQSA-N |
| Smiles | O[C@H]([C@]2=CC=CC=C2)C[C@@H]1CCC[C@H](CC(C3=CC=CC=C3)=O)N1C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 50 mM in ethanol and to 10 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 373.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.37 mL | 26.74 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.35 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582
Merck Index 12 5580 PMID:
Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674
Keywords: (-)-Lobeline hydrochloride, supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, partial, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
