Biological Activity
Selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent.
Compound Libraries
Losartan potassium is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 461 |
| Formula | C22H22ClKN6O |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 124750-99-8 |
| PubChem ID | 11476710 |
| InChI Key | OXCMYAYHXIHQOA-UHFFFAOYSA-N |
| Smiles | CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.1 | 100 | |
| water | 46.1 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 461. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.85 mL | 21.69 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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References
References are publications that support the products' biological activity.
Wong et al (1990) Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 255 584 PMID: 2243344
Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 252 719 PMID: 2179531
Rhaleb et al (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17 480 PMID: 1672862
Keywords: Losartan potassium, supplier, Selective, non-peptide, angiotensin, II, A-II, AT1, receptors, antagonists, AT-II, DuP753, DuP-753, Angiotensin, AT1, Receptors, Angiotensin, AT1, Receptors, Tocris Bioscience
