BiologicalActivity
Potent,competitiveinhibitorofHMG-CoAreductase(Ki=0.6nM)thereforedecreasescholesterolbiosynthesis,invitroandinvivo.DecreasesCDK2,4,6andcyclinElevelsandinducesG1arrestandapoptosisintumorcelllinesinvitro.Inactivelactamprodrugoflovastatinhydroxyacid,naturallybioactivatedinvivofollowingoraladmiNISTration.
CompoundLibraries
LovastatinisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 404.54 |
| Formula | C24H36O5 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 75330-75-5 |
| PubChemID | 53232 |
| InChIKey | PCZOHLXUXFIOCF-BXMDZJJMSA-N |
| Smiles | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.45 | 100 | |
| ethanol | 20.23 | 50mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight404.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.47mL | 12.36mL | 24.72mL |
| 5mM | 0.49mL | 2.47mL | 4.94mL |
| 10mM | 0.25mL | 1.24mL | 2.47mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |
MolarityCalculator
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ProductDatasheets
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