Biological Activity
Pro-opiomelanocortin (POMC) derived peptide. Potentiates the steriodogenic action of corticotrophin on the adrenal cortex, possibly via the MC3 receptor. Potently stimulates lipolysis via activation of hormone-sensitive lipase (HSL).
Technical Data
| M. Wt | 3018.27 |
| Formula | C128H193N45O39S |
| Sequence | KYVMGHFRWDRFGRRNSSSSGSSGAGQ |
| Storage | Store at -20°C |
| CAS Number | 156159-18-1 |
| PubChem ID | 90488867 |
| InChI Key | XWFHPHMLENMPDT-KLQUGMGCSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 10% acetonitrile / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3018.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.33 mL | 1.66 mL | 3.31 mL |
| 5 mM | 0.07 mL | 0.33 mL | 0.66 mL |
| 10 mM | 0.03 mL | 0.17 mL | 0.33 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.07 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Harmer et al (2008) Evidence of a possible role fo Lys-γ3-MSH in the regulation of adipocyte function. J.Endocrinol. 196 149 PMID: 18180326
Bicknell et al (2009) Lys-gamma3-MSH: a global regulator of hormone-sensitive lipase activity? Mol.Cell.Endocrinol. 300 71 PMID: 18977407
Harmer and Bicknell (2004) The role of the melanocortin 3 receptor in mediating the effects of gamma-MSH peptides on the adrenal. Endocrine Res. 30 629 PMID:
Keywords: Lys-gamma3-MSH, supplier, Pro-opiomelanocortin, POMC, hormone-sensitive, lipase, activators, HSL, melanocortin, receptors, Hydrolases, Lys-γ3-MSH, Lys-gamma3-MSH, Lys-γ3-Melanocyte-stimulating, Lys-gamma3-Melanocyte-stimulating, hormone, Melanocortin, Receptors, Other, Hydrolases, Melanocortin, Receptors, Tocris Bioscience
