Biological Activity
Selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists.
Technical Data
| M. Wt | 2287.64 |
| Formula | C108H163N27O28 |
| Sequence |
WTLNSAGYLLGPEHPPPALALA (Modifications: Ala-22 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 908844-75-7 |
| PubChem ID | 90477989 |
| InChI Key | BHKXASDHGWBINL-ZEHYZEGSSA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 30% acetonitrile |
Preparing Stock Solutions
The following data is based on the product molecular weight 2287.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.44 mL | 2.19 mL | 4.37 mL |
| 5 mM | 0.09 mL | 0.44 mL | 0.87 mL |
| 10 mM | 0.04 mL | 0.22 mL | 0.44 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.09 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 85 273 PMID: 16996122
Sollenburg et al (2006) M871 - a novel peptide antagonist selectively recognizing the galanin receptor type 2. Int.J.Pept.Res.Ther. 12 115 PMID:
Keywords: M871, supplier, Selective, GAL2, GalR2, antagonists, Receptors, Galanin, Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide, Galanin, Receptors, Galanin, Receptors, Tocris Bioscience
