Biological Activity
Selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.
Technical Data
| M. Wt | 197.13 |
| Formula | C5H12NO5P |
| Storage | Store at RT |
| Purity | ≥96% (HPLC) |
| CAS Number | 157381-42-5 |
| PubChem ID | 1795545 |
| InChI Key | HONKEGXLWUDTCF-YFKPBYRVSA-N |
| Smiles | N[C@](CCP(O)(O)=O)(C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 19.71 | 100 | |
| 1eq. NaOH | 19.71 | 100 | |
| water | 19.71 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 197.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.07 mL | 25.36 mL | 50.73 mL |
| 5 mM | 1.01 mL | 5.07 mL | 10.15 mL |
| 10 mM | 0.51 mL | 2.54 mL | 5.07 mL |
| 50 mM | 0.1 mL | 0.51 mL | 1.01 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jane et al (1994) Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord. Br.J.Pharmacol. 112 809 PMID: 7921606
Kemp et al (1996) Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur.J.Pharmacol. 309 79 PMID: 8864697
Salt and Eaton (1995) Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65 5 PMID: 7753406
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
Keywords: MAP4, supplier, Potent, group, II, mGlur, agonists, specific, III, antagonists, Selective, potent, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu4, mGluR4, mGlu6, mGluR6, mGlu7, mGluR7, mGlu8, mGlkuR8, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience
