![Tocris/[Ala113]-MBP (104-118)/1901/1/1 mg](https://www.ebiomall.cn/images/201712/1512520108811975211.jpg)
Biological Activity
Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).
Technical Data
| M. Wt | 1493.68 |
| Formula | C67H104N20O19 |
| Sequence | GKGRGLSLSAFSWGA |
| Storage | Desiccate at -20°C |
| CAS Number | 99026-78-5 |
| PubChem ID | 71312078 |
| InChI Key | FBVMKAAYUXGGSU-NBRSAOMZSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in 0.25% acetic acid |
Preparing Stock Solutions
The following data is based on the product molecular weight 1493.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.67 mL | 3.35 mL | 6.69 mL |
| 5 mM | 0.13 mL | 0.67 mL | 1.34 mL |
| 10 mM | 0.07 mL | 0.33 mL | 0.67 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.13 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Su et al (1986) Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C). Biochem.Biophys.Res.Commun. 134 78 PMID: 2418828
Turner et al (1985) Substrate specificity of phospholipid/Ca2+ dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein. J.Biol.Chem. 260 11503 PMID: 2413012
Keywords: [Ala113]-MBP (104-118), supplier, Protein, kinase, C, inhibitors, inhibits, PKC, Kinases, [Ala113]-MBP104-118, [Ala113]-Myelin, Basic, Protein, (104-118), Protein, Kinase, C, Protein, Kinase, C, Tocris Bioscience
