Biological Activity
Selective inhibitor of class IIa histone deacetylases (HDACs). Exhibits tissue-selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. Arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Displays no inhibition of class I HDAC activity or expression.
Compound Libraries
MC 1568 is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 314.31 |
| Formula | C17H15FN2O3 |
| Storage | Store at +4°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 852475-26-4 |
| PubChem ID | 11381449 |
| InChI Key | QRDAPCMJAOQZSU-KQQUZDAGSA-N |
| Smiles | CN1C=C(/C=C/C(C2=CC(F)=CC=C2)=O)C=C1/C=C/C(NO)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 314.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.91 mL | 31.82 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Mai et al (2005) Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamines. J.Med.Chem. 48 3344 PMID: 15857140
Mai et al (2007) Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia. Mol.Pharmacol. 72 1111 PMID: 17666592
Nebbioso et al (2009) Selective class II HDAC inhibitors may impaor myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO J. 10 776 PMID:
Keywords: MC 1568, supplier, MC1568, HDAC, selective, inhibitors, inhibits, histone, deacetylase, class, II, IIa, HDAC4, epigenetics, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience
