Biological Activity
Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
Technical Data
| M. Wt | 609.73 |
| Formula | C34H39N7O4 |
| Sequence |
XRX (Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 475498-26-1 |
| PubChem ID | 9938789 |
| InChI Key | FJFLYSMWSRRMRO-FRXPANAUSA-N |
| Smiles | CC(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in 25% ethanol / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 609.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.64 mL | 8.2 mL | 16.4 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 10 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID: 12909200
Keywords: MCL 0020, supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, MCL0020, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience
