Biological Activity
Sodium salt of (RS)-MCPG (Cat. No. 0336), a non-selective group I/group II metabotropic glutamate receptor antagonist.
Technical Data
| M. Wt | 253.16 |
| Formula | C10H9NNa2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1303994-09-3 |
| PubChem ID | 90488871 |
| InChI Key | YGOTXTUQJLFNHB-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].CC(N)(C([O-])=O)C1=CC=C(C=C1)C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.32 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 253.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.95 mL | 19.75 mL | 39.5 mL |
| 5 mM | 0.79 mL | 3.95 mL | 7.9 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.95 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Collingridge and Watkins (1994) Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 15 333 PMID: 7992387
Joly et al (1995) Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 15 3970 PMID: 7751958
Eaton et al (1993) Competitive antagonist at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol.Mol.Pharmacol.Sect. 244 195 PMID:
Keywords: (RS)-MCPG disodium salt, supplier, Non-Selective, mGlur, antagonists, Group, I, II, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
