Biological Activity
Active isomer of (RS)-MCPG (Cat. No. 0336). Non-selective group I/group II metabotropic glutamate receptor antagonist. Also available as part of the Group I mGlu Receptor Tocriset™, Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™.
Technical Data
| M. Wt | 209.2 |
| Formula | C10H11NO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 150145-89-4 |
| PubChem ID | 446355 |
| InChI Key | DNCAZYRLRMTVSF-JTQLQIEISA-N |
| Smiles | N[C@](C)(C(O)=O)C1=CC=C(C(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 20.92 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 209.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.78 mL | 23.9 mL | 47.8 mL |
| 5 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 10 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.96 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bordi et al (1996) Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology 35 1557 PMID: 9025103
Collingridge and Watkins (1994) Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 15 333 PMID: 7992387
Jane et al (1993) Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of 1S,3R-ACPD induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology 32 725 PMID: 7689710
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br. J. Pharmacol. 117 1493 PMID: 8730745
Keywords: (S)-MCPG, supplier, mGlur, Group, I, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, II, mGlu2, mGlu3, mGluR2, mGluR3, antagonists, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
