Biological Activity
NK2 tachykinin receptor selective antagonist.
Technical Data
| M. Wt | 745 |
| Formula | C40H56N8O6 |
| Sequence |
QWFGLL (Modifications: Leu-5 - Leu-6 = Leu-CH2N(CH3)-Leu, Cyclized) |
| Storage | Desiccate at -20°C |
| CAS Number | 135721-56-1 |
| PubChem ID | 90479769 |
| InChI Key | HTXNHRVBQSWFDI-QEQIFPIFSA-N |
| Smiles | CC(C)C[C@@H]1NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.50 mg/ml in acetonitrile / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 745. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.34 mL | 6.71 mL | 13.42 mL |
| 5 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 10 mM | 0.13 mL | 0.67 mL | 1.34 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.27 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Black et al (1992) Tachykinin receptors in rabbit airways - characterization by functional, autoradiographic and binding studies. Br.J.Pharmacol. 107 429 PMID: 1384914
Maggi et al (1993) MEN 10,573 and MEN 10,612, novel cyclic pseudopeptides which are potent tachykinin NK-2 receptor antagonists. Regul.Pept. 47 151 PMID: 8234901
Keywords: MDL 29,913, supplier, Selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MDL29913, NK2, Receptor, NK2, Receptor, Tocris Bioscience
