Biological Activity
5-HT3 antagonist.
Compound Libraries
MDL 72222 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 314.21 |
| Formula | C15H17Cl2NO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 40796-97-2 |
| PubChem ID | 1683 |
| InChI Key | MNJNPLVXBISNSX-UHFFFAOYSA-N |
| Smiles | CN1C2CCC1CC(C2)OC(=O)C1=CC(Cl)=CC(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 314.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.91 mL | 31.83 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.37 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fozard (1984) MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 326 36 PMID: 6472484
Richardson and Engel (1986) The pharmacology and function of 5-HT3 receptors. Trends Neurosci. 9 424 PMID:
Keywords: MDL 72222, supplier, 5-HT3, antagonists, Serotonin, Receptors, MDL72222, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
