Biological Activity
Polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Displays anticancer and neuroprotective activity in vivo.
Technical Data
| M. Wt | 265.23 |
| Formula | C12H20N2.2HCl |
| Storage | Desiccate at +4°C |
| CAS Number | 93565-01-6 |
| PubChem ID | 3035046 |
| InChI Key | ITVRWVVFVHINOH-UHFFFAOYSA-N |
| Smiles | C=C=CCNCCCCNCC=C=C.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.89 | 75 | |
| ethanol | 6.63 | 25 | |
| water | 26.52 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 265.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.77 mL | 18.85 mL | 37.7 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bey et al (1985) N-2,3-butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J.Med.Chem. 28 1 PMID: 3965702
Dogan et al (1999) Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J.Neurochem. 72 765 PMID: 9930751
Basu et al (2009) A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 69 7689 PMID: 19773450
Keywords: MDL 72527, supplier, MDL72527, polyamine, oxidases, inhibitors, inhibits, POA, Other, Oxygenases/Oxidases, Other, Oxygenases/Oxidases, Tocris Bioscience
